Is lymphadenectomy necessary for low-risk endometrial cancer?
Keywords:
endometrial cancer, lymphadenectomy, survivalAbstract
Objective: The aim of this study is to investigate the effect of lymphadenectomy on disease-free survival(DFS) and overall survival(OS) in low-risk endometrial cancer cases.
Material and Methods: Patients who were operated for endometrial carcinoma with endometrioid type, The International Federation of Gynecology and Obstetrics (FIGO) stage 1A, grade 1 or 2 histology between 1994 and 2013 were included in this study. The patients were divided into two groups as those who underwent intraoperative lymphadenectomy(LA +, n=197) and those who did not(LA -, n=133). Each group was evaluated in terms of survival times and recurrences.
Results: When the LA+ and LA - groups were compared in terms of survival, no significant difference was found between the two groups about DFS(p=0,955) and OS(p=0,937). The 5-year DFS rate was 95.1% in the LA - group and 94.9% in the LA+ group (P= 0.974). The 5-year OS rates in patients who did and did not undergo lymph node dissection were 96.8% and 97.0%, respectively, and no statistically significant difference was found between the groups (P= 0.551).
Conclusion: Performing lymphadenectomy in patients with FIGO stage 1A, grade 1 or 2, endometrioid adenocarcinoma has no effect on DFS and OS.
Key Words: Endometrial cancer, lymphadenectomy, survival
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